The first thing that came to mind when reading the title is "how do they detect? how can we crack it?" Much like anti-anti-debugging is a thing, perhaps adblockers also need to have anti-anti-adblock features.

...but things like this are why "remote attestation" and its ilk should be our biggest concern, because they can use such technologies to deny or distinguish anyone not using the --- no doubt already narrow and increasingly narrowing --- "supported" or "compliant" hardware and software.